Current situation of individualized vancomycin dosing via pharmacokinetic tool
10.13699/j.cnki.1001-6821.2018.01.017
- VernacularTitle:基于药代动力学方法支持的万古霉素个体化给药现状
- Author:
Na HE
1
;
Ying-Ying YAN
;
Shan SU
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
vancomycin;
pharmacokinetic;
therapeutic drug monitoring;
individualized dosing
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(1):63-65,69
- CountryChina
- Language:Chinese
-
Abstract:
Vancomycin (VCM) is the first-line therapy for invasive multi-resistant gram-positive bacterial infections involving Methicillinresistant Staphylococcus aureus.The therapeutic range of VCM is narrow,and its use is associated with nephrotoxicity.The pharmacokinetic characteristics of VCM vary greatly with renal function.Therapeutic drug monitoring and pharmacokinetic (PK) monitoring are required for maximizing its efficacy and minimizing adverse effect.Several studies focused on vancomycin individualized dosing have been published recently.The advances of vancomycin individualized dosing via PK tool are reviewed in this study.
