Effects of Rhubarb, Polygonum cuspidatum on hemodynamics and blood lipid in rats with blood stasis syndrome
10.13699/j.cnki.1001-6821.2018.01.010
- VernacularTitle:大黄和虎杖对血瘀症模型大鼠血流动力学和血脂的影响
- Author:
Gong-Xiao MO
1
;
Xiao-Jun HUANG
;
Qiu-Meng WEI
;
Zhi-Li LIANG
;
Meng-Yao LIN
;
Suo-Yi HUANG
Author Information
1. 右江民族医学院临床医学院
- Keywords:
Rhubarb;
Polygonum cuspidatum;
blood stasis syndrome;
hemorheology
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Rhubarb and Polygonum cuspidatum and their combination on blood stasis model rats.Methods Forty female SPF rats were chosen and were randomly divided into blank,model,test I,test Ⅱ,test Ⅲ groups,8 rats in each group.The rats of test I,test Ⅱ,test Ⅲ groups were given 30 mg · kg-1 Rhubarb drug,Polygonum,Rhubarb Polygonum cuspidatum (1:1),qd;blank and model groups were given 0.9％ NaCl at 5 mL · kg-1 dose,qd.The rats were treated for consecutive 10 days.After lavage for 1 h,except the blank group,the rats in other groups were given adrennaline hydrochloride 1mg · kg-1 by intraperitoneal injection.After 24 h,they were injected the same dose of adrenaline again.After the acute blood stasis model was prepared,the rats were anesthetized to collect blood from the abdominal aorta After anticoagulation treatment,the hemorheology index and lipid index of all samples were tested by automatic blood rheology tester and automatic biochemical analyzer.Results The blood biscosity in blank and test Ⅲ I groups were (3.26±1.33) and (4.51 ±1.15) mPa · s at 200/s,(4.21 ±1.41) and (5.80 ±1.44) mPa · s at 50/s,(9.75 ±2.97) and (13.27 ±3.14) mPa · s at 5/s,(25.58 ±7.24) and (34.49 ±7.95) mPa · s at 1/s,with significant difference (all P ＜ 0.05).The erythrocyte aggregation index in the blank,test Ⅰ,test Ⅱ groups were (8.04 ± 0.80),(7.39 ± 0.31) and (7.18 ± 0.62),respectively.The difference between the blank and test Ⅰ groups was statistically significant (P ＜ 0.05).The difference between the blank and test Ⅱ groups were highly statistically significant (P ＜0.01).Triglyceride in model,test Ⅱ groups were (0.92 ±0.39) and (0.61 ±0.15) mmol · L-1,with significant difference (P ＜ 0.05).Conclusion Rhubarb,Polygonum cuspidatum,and Rhubarb-Polygonum cuspidatum combination all had good effect on the rats with blood stasis syndrome,but Rhubarb-Polygonum cuspidatum combination (1:1) did not show the obvious synergistic effect.Polygonum cuspidatum can significantly reduce triglycerides,while Rhubarb alone didn't show the role of significant reduction of blood lipids,and in reducing blood lipids,rhubarb and in this regard,Polygonum cuspidatum compatibility didn't show the synergistic effect.
