Clinical efficacy and safety of tacrolimus capsule combined with mycophenolate mofetil capsule in the treatment of adult refractory nephropathy
10.13699/j.cnki.1001-6821.2018.01.002
- VernacularTitle:他克莫司胶囊联合吗替麦考酚酯胶囊治疗成人难治性肾病的临床疗效及安全性
- Author:
Ye LIN
1
;
Wen CHEN
;
Yi-Jun ZHUANG
;
Xue-Qin HU
;
Jun LI
Author Information
1. 海南医学院第二附属医院肾内科
- Keywords:
refractory nephropathy;
tacrolimus;
mycophenolate mofetil;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of tacrolimus capsule combined with mycophenolate mofetil capsule in the treatment of adult refractory nephropathy syndrome (RNS)Methods The 142 adult patients with RNS from the nephrology department in our hospital were selected and divided into two groups,71 cases in the control group treated with prednisone acetate tablets,1 mg · kg-1,qd,after 8 weeks of continuous treatment,10％ decrement every 2 weeks until to 10 mg · d-1,treated with tacrolimus capsules 50 μg · kg-1 · d-1,bid,oral.The 71 cases in the treatment group,on the basis of the control group,treated with mycophenolate mofetil capsules 0.5 g,bid,oral The levels of serum urea nitrogen (BUN),creatinine (SCr) and cystatin C (CysC) were detected by automatic biochemical analyzer.The 24 h urinary protein quantitation (24hUPQ) was detected by automatic urine analysis station.The serum levels of transforming growth factor β1 (TGF-β1),interleukin-2 (IL-2) and interleukin-8 (IL-8) were detected by enzyme linked immunosorbent assay.And the clinical efficacy and adverse drug reaction(ADR) rate were compared between two groups after the treatment.Results After treatment,the total effective rates in treatment group and the control group were respectively 88.73％ (63 cases/71 cases)and 76.06％ (54 cases/71 cases),the difference in two groups was statistically significant(P ＜ 0.05).After treatment,the serum SCr levels in the treatment group and the control group were(68.75 ± 8.32) and (77.03 ± 9.28) mol · L-1,24hUPQ levels were (0.82 ± 0.09)and (1.32 ±0.14)g/24 h in the two groups,the serum TGF-β1 levels were (33.95 ± 3.82) and (41.25 ±4.37) μg · L-1 in the two groups,the serum IL-2 levels were (154.35 ± 19.64)and (174.58 ±22.18)pg · mL-1 in the two groups,the differences in two groups were statistically significant(all P＜0.05).The incidence rates of ADR in treatment group and control group were respectively 15.50％(11 cases/71 cases) and 9.87％ (7 cases/71 cases),there was no statistical difference between the two groups (P ＞0.05).Conclusion Tacrolimus capsule combined with mycophenolate mofetil capsule are effective and safety in the treatment of adult RNS.
