Expression and significance of microRNA-130a and microRNA-130b in serum of patients with liver cirrhosis

VernacularTitle:微小RNA-130a和微小RNA-130b在肝硬化患者血清中的表达及其意义
Author: Xu-Lei HUO ¹ ; San-Qiang LI ; Xin-Jie QIAO ; Shan-Long WANG ; Yong-Yong ZHANG ; Ying SONG ; Fang-Yu CAI ; Hai-Kuan SUN ; Yi-Jiong ZHANG ; Qian TI
Author Information

1. 河南科技大学医学院肝损伤与修复分子医学重点实验室
Keywords: microRNA-130a; microRNA-130b; liver cirrhosis
From: The Chinese Journal of Clinical Pharmacology 2018;34(1):3-5
CountryChina
Language:Chinese
Abstract: Objective To study the expression and significance of microRNA-130a(miR-130a) and miR-130b in cirrhosis' serum.Methods The elbow vein blood of 15 cases of healthy subjects and 15 cases of patients with cirrhosis were collected and were divided into treatment group and control group respectively.Reverse transcription-polymerase chain reaction was used to detect the expression of miR-130a and miR-130b in serum.Results The relative expression of miR-130a in treatment group and control goup were (1.57 ±0.36)and (1.40 ± 0.46) and the relative expression of miR-130b in serum in treatment group and control group were (2.18 ± 0.60) and (1.64 ±0.26).The differences were statistically significant(P ＜0.05 or P ＜0.01).Conclusion The expression level of miR-130a and miR-130b in cirrhosis' serum is significantly higher than those in healthy person.It is likely to be used as a diagnostic marker for cirrhosis.