Research status of exosome-derived microRNA in diagnosis and treatment
10.13699/j.cnki.1001-6821.2017.24.024
- VernacularTitle:外泌体源性微小RNA在疾病诊治中的研究现状
- Author:
Han-Cheng LI
1
;
Yu-Ting ZHOU
;
Chan LI
;
Jin-Ying OU
;
Zhi-Xian MO
Author Information
1. 南方医科大学中医药学院,广州510515
- Keywords:
exosome;
cardiovascular diseases;
tumor;
central nervous system diseases;
microRNA
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(24):2646-2648,2652
- CountryChina
- Language:Chinese
-
Abstract:
Exosome is a nano-level vesicle composed of lipid bilayer layers.It is prevalent in plasma,urine,cerebrospinal fluid and other body fluids.The microRNAs(miRNAs) wrapped in the exosomes can be taken up by the target cellsand play their role through silencing target gene as endogenous miRNAs.Exosomes can promote information exchange between organs or cells by carrying miRNA,participating in the process of angiogenesis,cell migration and communication.In this paper,the author briefly reviewed the application of exogenous maternal miRNAs in the diagnosis and treatment of cardiovascular system diseases,central nervous system diseases and tumor in the recent years.
