Glucose-regulated protein 78 and cytochrome P450 for tumor chemotherapy resistance in endoplasmic reticulum
10.13699/j.cnki.1001-6821.2017.24.022
- VernacularTitle:葡萄糖调节蛋白和细胞色素P450酶在肿瘤化疗耐药中的研究进展
- Author:
Yu-Qing OUYANG
1
;
Han HU
;
Guo-Liang ZHANG
Author Information
1. 北京大学医学部基础医学院药理学系,北京100191
- Keywords:
glucose-regulated protein 78;
cytochrome P450 enzyme;
endoplasmic reticulum stress;
anti-tumor chemotherapy resistance
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(24):2637-2641
- CountryChina
- Language:Chinese
-
Abstract:
Glucose-regulated protein 78 (GRP78) exerts critical influence on endoplasmic reticulum stress (ER stress),carcinogenesis and tumor progression.Cytochrome P450 (CYP450) enzyme is of great importance in the metabolism of drug and carcinogens.This article reviews recent studies on the interaction between GRP78 and CYP450 in order to provide evidence of novel strategies for cancer treatment.
