Antitumor effect of kaempferol on H22 tumor-bearing in mice in vivo
10.13699/j.cnki.1001-6821.2017.24.013
- VernacularTitle:山萘酚对H22荷瘤小鼠的体内抗肿瘤作用
- Author:
Li-Xiang YE
1
;
Guan-Yu RUAN
;
Xiao-Dan MAO
;
Xu-Hui SONG
;
Li-Wei TANG
Author Information
1. 福建医科大学福建省新药安全性评价中心,福州350122
- Keywords:
kaempferol;
H22 liver cancer;
anti-tumor;
ascetic tumor;
solid tumor
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(24):2603-2605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of kaempferol on tumor growth,weight,liver index (LI) and spleen index (SI) in different models of H22 tumor-bearing mice.Methods The H22 ascitic and solid tumor-bearing mice model were established,then mice were randomized into five groups,including model group,control group (cyclophosphamide 30 mg · kg-1),experimental-L,-M,-H groups (kaempferol 150,300,600 mg · kg-1).The samples were obtained in 24 h after continuous intragastrical administration of drug or solvent to mice for 8 d.The ascitic volume and tumor weight were measured.The liver index(LI),spleen index (SI) were calculated.Results In H22 ascitic tumor-bearing mice,the ascitic volume of mice in model group,control group,experimental-L,-M,-H groups were (9.85 ± 1.99),(2.28 ±2.74),(8.44 ±2.51),(5.91 ±2.29),(4.98 ±4.25) mL;compared with model group,the difference in control group,experimental-M,-H groups was significantly (all P ＜ 0.05).LI and SI in above five groups were 4.72 ± 2.22,5.42 ±0.77,4.69 ± 0.94,5.22 ± 0.60,5.27±0.61;0.49 ±0.33,0.62 ±0.19,0.51 ±0.13,0.49 ±0.14,0.41 ±0.14 with not significantly between five groups(all P ＞0.05).In H22 solid tumor-beating mice,the tumor weight of mice in model group,control group,experimental-L,-M,-H groups were (1.70 ± 0.80),(0.73 ±0.51),(1.14 ±0.91),(1.07 ±0.34),(0.95 ±0.60) g with significantly compared with model group(all P ＜ 0.05).Conclusion The kaempferol had anti-tumor effects toward H22 tumor-bearing mice with less influence on liver and spleen.
