Antimicrobial susceptibility of Gram-positive organisms: results from China antimicrobial resistance surveillance trial program, 2015-2016
10.13699/j.cnki.1001-6821.2017.23.057
- VernacularTitle:中国细菌耐药监测研究2015-2016革兰氏阳性菌监测报告
- Author:
Yun LI
1
;
Yuan L(U)
;
Bo ZHENG
;
Feng XUE
;
Xiu-Zhen ZHANG
;
Yun-Jian HU
;
Ting YU
;
Zhi-Dong HU
;
Jian-Hong ZHAO
;
Shi-Yang PAN
;
Hua-Yin LI
;
Yun-Song YU
;
Yan LI
;
Wen-En LIU
;
De-Hua LIU
;
Ying FEI
;
Wei-Ling FU
;
Xiu-Li XU
;
Feng-Yan PEI
;
Ling MENG
;
Ping JI
;
Jin TANG
;
Hui-Qun FU
;
Jian LIU
;
Wei-Wei YANG
;
Jia ZHANG
Author Information
1. 北京大学第一医院临床药理研究所,北京100191
- Keywords:
antimicrobial resistance surveillance;
Gram-positive cocci;
minimum inhibitory concentration;
susceptibility;
resistance;
minimum inhibitory concentration distribution
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2543-2556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the gram-positive coccus resistance in nationwide's tietiary hospitals and understand the trend of antimicrobial resistance.Methods All the clinical isolates were collected from 18 hospitals and the minimal inhibitory concentrations (MICs) were tested using agar/broth dilution method recommended by Clinical and Laboratory Standards Institute (CLSI) in central laboratory.The susceptibilities of isolates to antimicrobial agents were determined by using CLSI or European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2017 guideline.Results A total of 2301 Gram-positive cocci isolated from 18 hospitals in 18 cities nationwide were studied.Based on the MIC results,the prevalence of methicillin resistant Stapylococcus aureus (MRSA) and methicillin resistant Stapylococcus epidermidis (MRSE) were 39.9％ and 86.6％ respectively.No vancomycin insensitive Staphylococcus was detected.Staphylococcus aureus were 100％ susceptibile to linezolid and teicoplanin,but resistant or insensitive for drugs other than vancomycin were observed among Coagulase Negative Staphylococci (CoNS).Antibiotic resistance rate of Enterococcus faecalis and Enterococcusfaecium to ampicillin were 4.5％ and 85.1％.The detectation rate of vancomycin resistant Enterococcus(VRE) was 2.1％.Nonsusceptibility rate of Enterococcus faecalis to linezolid was 7.8％,showing slight increase than last time.The prevalence of penicillin nonsusceptible Streptococcus pneumoniae (PNSSP) was 6.6％ based on non-meningitis and parenteral administration criterion;while for cases of oral penicillin,the rate was 70.0％,was as flat as last time.There were no significant differenees of resistance rates of Stapylococcus aureus,Stapylococcus epidermidis Enterococcus faecalis and Enterococcus faecium among various groups such as different department,age,or specimen source.Conclusion Compared with past surveillance result,VRE detection ratio was steady,while MRSA detection ratio decreased.The emergence of resistance and non-susceptible strains to new antibiotics such as linezolid,tigecycline and daptomycin should be payed more attention.
