Antimicrobial susceptibility of Gram-negative organisms: Results from China antimicrobial resistance surveillance trial program, 2015-2016
10.13699/j.cnki.1001-6821.2017.23.056
- VernacularTitle:中国细菌耐药监测研究2015-2016革兰氏阴性菌监测报告
- Author:
Yun LI
1
;
Yuan L(U)
;
Bo ZHENG
;
Feng XUE
;
Xiu-Zhen ZHANG
;
Yun-Jian HU
;
Ting YU
;
Zhi-Dong HU
;
Jian-Hong ZHAO
;
Shi-Yang PAN
;
Hua-Yin LI
;
Yun-Song YU
;
Yan LI
;
Wen-En LIU
;
De-Hua LIU
;
Ying FEI
;
Wei-Ling FU
;
Xiu-Li XU
;
Feng-Yan PEI
;
Ling MENG
;
Ping JI
;
Jin TANG
;
Hui-Qun FU
;
Jian LIU
;
Wei-Wei YANG
;
Jia ZHANG
Author Information
1. 北京大学第一医院临床药理研究所,北京100191
- Keywords:
antimicrobial resistance surveillance;
Gram-negative organisms;
minimum inhibitory concentration;
susceptibility;
resistance;
minimal inhibitory concentration distribution
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2521-2542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antibacterial resistance in nationwide's tietiary hospitals and understand the trend of antimicrobial resistance.Methods All the clinical isolates were collected from 18 hospitals and the minimal inhibitory concentrations (MICs) were tested using agar dilution method recommended by Clinical and Laboratory Standards Institute (CLSI) in central laboratory.The susceptibilities of isolates to antimicrobial agents were determined by using CLSI or European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2017 guideline.Results A total of 4333 pathogenic isolates from 18 tertiary hospitals in 18 cities nationwide over the period from July 2015 to June 2016 were studied.Based on the MIC results,Escherichia coli and Klebsiella pneumoniae showed extended spectrum β-lactamase (ESBLs) phenotype rates of 59.4％ and 27.5％,respectively;decreased by 7 to 10 percentage points comparing the last time.Carbapenems,amikacin,moxalactam,β-lactam/β-lactamase inhibitor combinations,tigecycline,and fosfomycin displayed desirable antibacterial activity against Enterbacteriaceae,but a significant increasing of carbapenems resistance Klebsiella pneumoniae were noted.For non-fermenting Gram-negative isolates,resistance rate of Pseudomonas aeruginosa and Acinetobacter baumannnii to imipennnem were 29.5％ and 69.8％ and multidrug-resistant (MDR) detection rate were 35.6％ and 78.3％,extensively drug-resistant (XDR) were 10.2％ and 72.5％,respectively.Klebsiella pneumoniae isolated from children were more resistant to β-lactam than those from adults and the old people,so bacterial resistance in children is an important problem in China.Conclusion Though the decline of ESBLs detection rate,carbapenem non-susceptible Klebsiella pneumoniae rates continued to increase,which should be paid more attention.
