Application status of pharmacogenomics in clinical researches of new drugs

VernacularTitle:药物基因组学在新药临床研究中的应用现状
Author: Xiao-Dan ZHANG ¹ ; Qian XIANG ; Kun HU ; Xia ZHAO ; Yi-Min CUI
Author Information

1. 北京大学第一医院药剂科,北京100034
Keywords: pharmacogenomics; new drug research and development; clinical research; clinical trial
From: The Chinese Journal of Clinical Pharmacology 2017;33(23):2508-2510
CountryChina
Language:Chinese
Abstract: Pharmacogenomics (PGx) mainly studies the influence of gene polymorphisms and other genetic characteristics on drug metabolism,efficacy and adverse drug reactions,and aims to provide scientific basis for new drug research and development,clinical trials,registration,and indivi-dualized drug therapy.With the vigorous development of the pharmaceutical industry,PGx has been more and more applied not only in the research and development of new drugs but also in drug post-marketed re-evaluation.PGx can greatly shorten the drug development cycle,reduce the cost of new drug research,and help to optimize the clinical application of drug therapy to improve safety and efficacy.This paper reviews on the specific application of PGx in various stages of clinical research and its developmental prospect.