Pathway of vancomycin dosage decision based on therapeutic drug monitoring
10.13699/j.cnki.1001-6821.2017.23.047
- VernacularTitle:基于治疗药物监测制定万古霉素给药方案路径研究
- Author:
Chao ZHANG
1
;
Ai-Lian SHAN
Author Information
1. 北京大学第三医院药剂科,北京100191
- Keywords:
vancomycin;
therapeutic drug monitoring;
pathway of dosage decision
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2484-2488
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop the pathway of vancomycin dosage decision based on therapeutic drug monitoring (TDM) in order to improve the clinic operability.Methods To systematically study the TDM target of vancomycin and their variances among populations,infusion approach and decided factors of dosing.Results It was found that area under curve/minimum inhibitory concentration (AUC/MIC) was a more accurate target compared to trough concentration for vancomycin.The trough concentration of 10-15 mg · L-1 may not be enough.The pathway of vancomycin dosage decision had been developed based on patients' characteristics.The simple calculation approach was relative inaccurate but simple and efficiency.The pharmacokinitc/pharmacodynamic (PK/PD) modeling approach was more accurate but relative complex and needing supportive software.The special parameters need to be considered for special populations.Conclusion The pathway of vancemycin dosage decision based on TDM have been developed and it can be used to improve the clinic operability and provide clear decision path for clinics.
