Review of sodium glycididazole combined with radiotherapy in the treatment of esophageal cancer
10.13699/j.cnki.1001-6821.2017.23.038
- VernacularTitle:甘氨双唑钠联合放疗治疗原发性食管癌的评价
- Author:
Jing LIU
1
;
Ting WANG
;
Ke-Fu YU
;
Yue TIAN
;
Ji-Ping HUO
Author Information
1. 首都医科大学附属北京天坛医院药学部,北京100050
- Keywords:
sodium glycididazole;
esophageal cancer;
radiation therapy;
system review
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2452-2454
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness of sodium glycididazole combined with radiotherapy in the treatment of esophageal cancer.Methods RCTs were retrieved from EMbase,PubMed,Cochrane Library,CNKI,VIP,Wanfang database.RCTs about sodium glycididazole combined with radiotherapy in the treatment of esophageal cancer were included.The schedule for treatment group was sodium glycididazole combined with radiotherapy,and that for control group was radiotherapy only.The complete remission rate (CR),total remission rate and incidence of adverse reaction were the combined effect amount and they were evaluated by using Rev Man 5.3 statistical software.Results A total of 9 RCTs were included,which involved 854 patients.Meta-analysis showed that odds ratio of esophageal cancer for both treatments group and control group were 54.22％ (244 cases/450 cases) and 28.46％ (115 cases/404 cases) respectively.Toial remission rate for both groups were 96.44％ (434 cases/450 cases) and 80.41％ (324 cases/404 cases),with significant difference (all P ＜ 0.05).The incidences of adverse reactions were 49.42％ (86 cases/174 cases) in treatment group and 55.83％ (67 cases/120 cases) in control group which had no significant difference(P ＞0.05).Conclusion Short-term efficacy of sodium glycididazole combined with radiotherapy was better than that by radiotherapy alone for esophageal cancer.
