Clinical trial of mifepristone in the treatment of patients with endometriosis
10.13699/j.cnki.1001-6821.2017.23.014
- VernacularTitle:米非司酮治疗子宫内膜异位症的临床研究
- Author:
Lian FU
1
;
Ruo-Heng ZHENG
Author Information
1. 恩施土家族苗族自治州民族医院妇产科,湖北恩施445000
- Keywords:
endometriosis;
mifepristone;
suppressor of cytokine signaling-3;
B cell lymphoma-2/B cell lymphoma-2 associated X protein;
caspase-3
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2375-2377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of endometriosis mifepristone and its effects on B cell lymphoma-2/B cell lymphoma-2associated X protein (Bcl-2/Bax),suppressor of cytokine signaling-3 (SOCS-3) and caspase-3.Methods One hundred and forty patients with endometriosis were divided into treatment group and control group,70 cases in each group.Treatment group was treated with mifepristone 10 mg orally,qd.Control group was treated with tamoxifen 10 mg each time orally,bid.All patients were treated for six months.The clinical efficacy and the levels of SOCS-3,Bcl-2/Bax,caspase-3 were observed in two groups before and after treatment.Results After treatment,the clinical efficacy in treatment group and control group were 85.71％ (60 cases/70 cases),81.43％ (57 cases/70 cases),without significant difference (P ＞0.05).After treatment,SOCS-3,Bcl-2/Bax and caspase-3 in treatment group were 7.62 ± 1.31,0.82 ± 0.22,5.52 ± 1.22,had significant difference with those in control group,which were 6.32 ±l.48,1.61 ±0.13,3.21 ± 1.87 (P ＜0.05).During the treatment,there were 1 case of nausea and 1 case of headache in treatment group,with the incidence of 2.86％ (2 cases/70 cases).There were 5 cases of vomiting,3 cases of shortness breath,1 case of vulvar itching in control group,with the incidence of 12.86％ (9 cases/70 cases).There was significant difference in the incidence of adverse drug reactions between the two groups (P ＜ 0.05).Conclusion The clinical efficacy of mifepristone in the treatment of endometriosis patients is great,mainly through the regulation of SOCS-3,Bcl-2/Bax,caspase-3 expression.
