Clinical trial of latamoxef sodium injection combined with metronidazole tablets in the treatment of children with intestinal ganglion cell disease
10.13699/j.cnki.1001-6821.2017.23.012
- VernacularTitle:拉氧头孢钠注射剂联合甲硝唑片治疗肠无神经节细胞症患儿的临床研究
- Author:
Hong-Tu MA
1
;
Xiao-Qing LI
;
Yi WANG
;
Wei LIU
;
Zhen-Hua GUO
Author Information
1. 重庆医科大学附属儿童医院胃肠新生儿外科,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆市儿童发育重大疾病诊治与预防国际科技合作基地,重庆400014
- Keywords:
latamoxef sodium injection;
metronidazole tablet;
intestinal ganglion cell disease;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2368-2370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of latamoxef sodium injection combined with metronidazole tablets in the treatment of intestinal ganglion cell disease.Methods A total of 90 patients with intestinal ganglion cells were randomly divided into control group and treatment group,with 45 cases per group.All patients were treated with laparoscopic assisted radical resection of the large intestine.After operation,control group was given metronidazole 0.4 g,tid,orally.The treatment group was given latamoxef sodium injection 2.0 g,qd,intravenous injection,on the basis of control group.Two groups were treated for 21 d.The clinical efficacy and adverse drug reactions in two groups were compared.Results After treatment,the total effective rates in treatment group and control group were 93.33％ (42 cases/45 cases) and 80.00％ (36 cases/45 cases),with significant difference (P ＜0.05).The main adverse drug reactions in treatment group were enterocolitis,constipation and urinary retention,with the incidence of 8.89％ (4 cases/45 cases).The adverse drug reactions in control group were small bowel disease,rectal muscle sheath infection,constipation and urinary retention,with the incidence of 31.11％ (14 cases/45 cases).The difference was statistically significant between the two groups (P ＜ 0.05).Conclusion The combination of cefotaxime sodium and metronidazole could improve the therapeutic effect and reduce the incidence of adverse drug reactions.
