Clinical trial of insulin glulisine combined with insulin glargine in the treatment of type 2 diabetes patients with secondary failure to oral hypoglycemia agents
10.13699/j.cnki.1001-6821.2017.23.010
- VernacularTitle:谷赖胰岛素联合甘精胰岛素治疗口服降糖药物继发性失效的2型糖尿病的临床研究
- Author:
Shu-Long GUO
1
;
You-Xiao ZENG
;
Shao-Ya WANG
;
Yun-Zong LIAN
;
Xue-E HUANG
;
Shu-Yan WU
Author Information
1. 福建医科大学附属泉州第一医院七病区,福建泉州362000
- Keywords:
insulin glulisine;
insulin aspart;
type 2 diabetes mellitus;
secondary failure to oral hypoglycemia agent
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2361-2363,2386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy and safety of insulin glulisine (GLU) and insulin aspam(ASP) combined with insulin glargine (GLA) in type 2 diabetes patients (T2DM) with secondary failure to oral hypoglycemic agents.Methods One hundred and twenty cases of T2DM with secondary failure to oral hypoglycemia agents were randomly divided into control group (n =60 cases) and treatment group (n =60 cases).The control group received subcutaneous injection of ASP before 0-10 min three meals daily,and the treatment group received subcutaneous injection of GLU before 0-10min three meals daily.The two groups were treated with subcutaneous injection of GLA,once daily.The initial dose of ASP and GLU were 0.8 U · kg-1 · d-1,and the initial dose of GLA was 0.2 U · kg-1 · d-1.Two groups of patients were hospitalized for 2 weeks.The changes of blood glucose,cases and days of blood glucose of achieving target were compared after treatment of hospitalization.The improvement of HbAlc and the frequency of hypoglycemia were observed after treatment of 12 weeks.Results The days of 2-hour postprandial blood glucose(2 h PG) of achieving target in the treatment group and the control group were (10.01 ± 1.99)d and (10.93 ± 1.52)d with 57 cases and 47 cases,and the days of fasting plasma glucose,postprandial blood glucose and 2 h PG of achieving target were (10.31 ± 1.04) d and (11.03 ± 1.38) d with 48 cases and 40 cases(all P ＜ 0.05).After treatment 12 weeks,the HbAlc in treatment and control groups were (6.78 ±0.59)％ and (7.07 ±0.49)％ without significant difference (P ＞ 0.05).During treatment of 12 weeks,the adverse drug reactions in the two groups were mainly hypoglycemic events,the incidence of hypoglycemia in the treatment group was 30.00％,and 25.00％ in the control group,the difference was not statistically significant (P ＞ 0.05).Conclusion Both GLU combined with GLA or ASP combined with GLA have similar efficacy and safety for T2DM with secondary failure to oral hypoglycemic agents.GLU combined with GLA is more rapid in controlling 2 h PG of these patients.
