Expression of E-cadherin in esophageal cancer tissue and its relationship with postoperative recurrence
10.13699/j.cnki.1001-6821.2017.23.009
- VernacularTitle:E-钙黏蛋白在食管癌组织中的表达及其与食管癌术后复发的相关性
- Author:
Yan-Bing HAO
1
;
Li WANG
;
Yu RONG
;
Dong WEI
;
Yan-Ming LI
;
Wan-Sheng CHEN
Author Information
1. 河北北方学院附属第一医院胸外科,河北张家口075000
- Keywords:
esophageal cancer;
E-cadherin;
expression;
recurrence
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2357-2360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of E-cadherin (E-cad) in esophageal cancer tissue and its relationship with postoperative recurrence.Methods Sixty cases of esophageal cancer patients who underwent surgical treatment and retained complete tumor tissue slice in our hospital from October 2014 to October 2015 were selected,60 cases of tumor tissue,20 cases of adjacent normal tissue.The expression of E-cad in esophageal cancer tissue and adjacent normal tissue was detected by immunohistochemistry.Results The positive expression rate of E-cad in esophageal squamous cell carcinoma tissue was 43.33％ (26 cases/60 cases),significantly lower than 85.00％ (51 cases/60 eases) in adjacent normal tissue (P ＜0.01).The expression of E-cad in high/ medim differentiation and poor differentiation,depth of invasion without muscle and deep muscle layer,lymph node metastasis or not had significant difference (P ＜0.05 or P ＜0.01).There was no significant difference in the expression of E-cad between less than Ⅲ period and Ⅲ and more period (P＞0.05).The positive expression rate of E-cad was 32.00％ (8 cases/ 25 cases) in recurrence group,lower than 51.43％ (18 cases/35 cases) in no recurrence group,but there was no significant difference (P ＞ 0.05).Conclusion The expression of E-cad in esophageal cancer tissue is down-regulated,and is related to the degree of tumor differentiation,depth of myometrial invasion and lymph node metastasis whether or not,but it's not directly related to postoperative recurrence.
