Effects of tranexamic acid on bleeding volume and postoperative coagulation function after liver resection in patients with hepatocellular carcinoma
10.13699/j.cnki.1001-6821.2017.23.007
- VernacularTitle:氨甲环酸对肝癌患者肝切除手术出血量及术后凝血功能的影响
- Author:
Xu-De WANG
1
;
Hua-Gao LIU
;
You-Zhi FANG
;
Sheng-Bing KONG
;
Xun WU
;
Yong-Yi HU
Author Information
1. 安徽卫生健康职业学院附属医院普外科,安徽池州247099
- Keywords:
tranexamic acid;
liver cancer;
liver resection;
bleeding volume;
postoperative coagulation
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2351-2353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of tranexamic acid on the blood loss and coagulation function after liver resection in patients with hepatocellular carcinoma (HCC).Methods Seventy patients with hepatectomy who underwent liver resection were randomly divided into control group and treatment group,each group 35 cases.Control group was given 0.9％ NaCl injection 10 mg · kg-1.Treatment group was given tranexamic acid 10 mg · kg-1.Two groups were used at half an hour before operation.The surgical bleeding volume and postoperative coagulation function between two groups were compared.Results The operation time,time of hilar occlusion in treatment group were (157.98 ±22.36),(30.14 ±5.64) min,had no significant difference with those in control group,which were (154.98 ± 23.65),(28.79 ± 5.79) min (P ＞ 0.05).The surgical blood transfusion,bleeding volume,infusion of erythrocyte suspension in treatment group were (879.65 ± 59.36) mL,(768.97 ± 45.65) mL,(1.36 ± 0.59) U,had significant differences with those in control group,which were (1054.91 ±61.32) mL,(869.64 ±46.69) mL,(2.01 ±0.65) U (all P ＜0.05).The percentage of activated thromboplastin (APTT),prothrombin time (PT),platelet (PLT) in treatment group at 24 h after operation were (41.56 ±5.46)s,(13.48 ±3.16)s,(167.89 ±35.87) × 109/L,had no significant difference with those in control group,which were (43.19 ± 5.69) s,(14.59 ± 2.49) s,(162.35 ± 41.59) × 109/L (all P ＞0.05).The fibrinogen (FIB) in treatment group and control group were (3.27 ±0.56),(3.01 ±0.59)g · L-1,with significant difference (P ＜ 0.05).There was no adverse drug reactions in two groups during the treatment.Conclusion Giving methotrexate injection to hepatocarcinoma patients before liver resection can reduce the amount of surgical bleeding,and improve the patients' postoperative coagulation function.
