Clinical trial of interferon combined with Tanreqing injection in the treatment of children with severe hand-foot-mouth disease
10.13699/j.cnki.1001-6821.2017.23.005
- VernacularTitle:重组人干扰素联合痰热清注射液治疗小儿重症手足口病的临床研究
- Author:
Hui-Ming QIU
1
;
Yi-Hong ZHU
Author Information
1. 湖州市中心医院儿科,浙江 湖州313000
- Keywords:
Tanreqing injection;
interferon;
serum inflammatory cytokines;
troponin Ⅰ;
severe hand-foot-mouth disease in children
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2343-2346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of Tanreqing injection combined with interferon on serum inflammatory cytokines and troponin Ⅰ in the treatment of children with severe hand-foot-mouth disease.Methods A total of 164 children with severe hand-foot-mouth disease were randomly divided into control group and treatment group,82 cases in each group.Patients in two groups were given regular treatment and symptomatic treatment,vitamin and electrolytes administration,oral and skin care,and the implementation of specialist care.Patients in control group were given ribavirin 10 mg · kg-1,muscle injection,qd.Patients in treatment group were received Tanreqing injection 0.5 mL · kg-1 + 5％ glucose injection 250 mL,qd and interferon α-2b injection 8.0 × 104 U · kg-1,muscle injection qd.Patients in two groups were treated for 6 d.After treatment,the clinical efficacy,levels of serum amyloid A (SAA),C-reactive protein (CRP),interleukin-6 (IL-6),interferon-γ(INF-γ),interleukin-1β (IL-1β),cardiac troponin Ⅰ (cTn Ⅰ) and adverse drug reactions were compared between the two groups.Results After treatment,the clinical efficiency in treatment group and control group were 92.68％ (76 cases/86 cases) and 73.17％ (60 cases/86 cases),with significant difference (P ＜0.05).Compared with control group,the body temperature,the rash subsided time,normal eating time,oral ulcer healing time and the average hospitalization time in treatment group were significantly shortened (P ＜ 0.05).After treatment,the levels of SAA,CRP,IL-6,INF-γ,IL-1β,cTn Ⅰ in control group were (298.39 ± 23.57) mg · L-1,(8.01 ± 0.87) mg · L-1,(141.29 ± 15.34) μg · L-1,(11.30 ± 1.37) μg · L-1,(57.93 ± 6.58) ng · mL-1,(0.46 ± 0.06) ng · mL-1,had significant differences with those in treatment group,which were (140.39 ± 15.39)mg · L-1,(4.78 ± 0.50) mg · L-1,(111.20 ± 14.29) μg· L-1,(5.40 ±0.67) μg · L-1,(28.09 ±3.19)ng · mL-1,(0.20 ±0.03) ng· mL-1 (all P ＜ 0.05).There were 4 cases of appetite loss,2 cases of eosinophilia,2 cases of gastric colic in treatment group,with the incidence of 9.76％ (8 cases/82 cases).There were 4 cases of appetite loss,2 cases of gastric colic,4 cases of nausea and vomiting,with the incidence of 12.20％ (10 cases/82 cases).There was no significant difference between the two groups (P ＞ 0.05).Conclusion Tanreqing injection combined with interferon in the treatment of severe hand-foot-mouth disease in children was effective with high safety.
