Clinical trial of simvastatin tablets combined with Wuling powder in the treatment of heart valve replacement
10.13699/j.cnki.1001-6821.2017.23.004
- VernacularTitle:辛伐他汀片联合五苓散用于心脏瓣膜置换术术后的临床研究
- Author:
Xian-Hong TANG
1
;
Li CONG
;
Wei-Dong MA
Author Information
1. 贵州工程职业学院医学院,贵阳550008
- Keywords:
simvastatin tablet;
Wuling powder;
heart valve replacement;
hemodynamics;
blood lipid;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2339-2342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of simvastatin tablets combined with Wuling powder in cardiac valve replacement.Methods A total of 100 patients with cardiac valve replacement were randomly divided into control group and treatment group with 50 cases per group.Control group was orally given simvastatin tablets 10 mg per time,bid,1 week before operation and from 2 days after operation for 1 week.Treatment group was orally given Wuling powder 6 g per time,tid,1 week before operation and from 2 days after operation for 1 week,on the basis of control group.The hemodynamic indexes,blood lipid indexes and adverse drug reactions were compared between two groups.Results Three days after operation,the main indexes in treatment and control groups were compared:whole high viscosity were (6.06 ±0.26) and (7.70 ±0.42) mPa · s,whole low viscosity were (10.31 ±0.35) and (12.30 ±0.38) mPa · s,plasma viscosity were (1.30 ± 0.23) and (2.69 ± 0.20) mPa · s,hematocrit were (46.59 ± 1.20) ％ and (52.97 ±0.65)％,with significant difference (all P ＜ 0.05).One week after operation,the main indexes in treatment and control groups were compared:total cholesterol were (5.62 ± 0.21) and (6.11 ± 0.27) mmol · L-1,triglyceride were (1.76 ± 0.21) and (2.26 ± 0.24) mmol · L-1,low density lipoprotein cholesterol were (2.23 ±0.21) and (2.87 ± 0.23) mmol · L-1,high density lipoprotein cholesterol were (1.18 + 0.07) and (0.94 ±0.06) mmol · L-1,with significant difference (all P ＜ 0.05).The adverse drug reactions in treatment group were abdominal pain,constipation and fatigue,which in control group were constipation and abdominal pain.The incidences of adverse drug reactions in treatment and control groups were 4.00％ and 6.00％ without significant difference (P ＞ 0.05).Conclusion Simvastatin tablets combined with Wuling powder can significantly improve hemodynamics and blood lipid in patients with cardiac valve replacement,without increasing the incidence of adverse drug reactions.
