Application of pharmacokinetics to guide the clinical trial of drugs in special population
10.13699/j.cnki.1001-6821.2017.22.029
- VernacularTitle:应用特殊人群的药代动力学指导药物临床试验
- Author:
Xi-Wei JI
1
;
Shuang-Min JI
;
Xiang-Rui MENG
;
Yuan L(U)
;
Chi-Shing CAO
Author Information
1. 北京大学第一医院临床药理研究所
- Keywords:
pharmacokinetics;
patients with impaired hepatorenal function;
elderly people;
pregnant women;
pediatric population
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(22):2321-2324
- CountryChina
- Language:Chinese
-
Abstract:
The individual pathological and physiological characteristics of different patient population can significantly affect the pharmacokinetic (PK) behavior.Although the PK study results from healthy subjects play an important role in guiding clinical rational medication,they may not be necessarily applicable to the population of elderly,children and gravida,and may not be suitable for all morbid states.Therefore,this article will review the PK clinical studies of various special population.
