Research advances of the interaction between serpin peptidase inhibitor clade E and cell signal transduction pathway
10.13699/j.cnki.1001-6821.2017.22.028
- VernacularTitle:丝氨酸蛋白酶抑制剂亚家族E与细胞信号转导通路相互作用的研究进展
- Author:
Mu-Ge QILI
1
;
Ying ZHANG
;
Xiao-Qiang E
;
Xue-Lian LI
Author Information
1. 哈尔滨医科大学药学院药理教研室、心血管药物研究教育部重点实验室
- Keywords:
plasminogen activator inhibitor;
protein nexin-1;
cell signaling pathway
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(22):2318-2320
- CountryChina
- Language:Chinese
-
Abstract:
Serpin peptidose inhibitor clade E (SERPINE),a kind of serpin peptidase inhibitors,belongs to the SERPIN super family,which have important impact on various significant biochemical responses and physiological functions in vivo.Research shows that SERPINE is widely expressed in a variety of tissues and cells,such as smooth muscle,cardiac muscle,liver,kidney,bone,blood cells,bone marrow stem cells,tumor tissue and so on.This paper mainly introduced the regulating effects and research progress of SERPINE1 (PAI-1),SERPINE2 (PN-1) and SERPINE3 in cell signal transduction pathways.
