Comparison of methods for the determination of sample size and power in assessing the equivalence of average bioavailability
10.13699/j.cnki.1001-6821.2017.22.021
- VernacularTitle:平均生物等效性研究中样本量和把握度估算方法比较
- Author:
Min-Ji WEI
1
;
Rui-Rui HE
;
Pu ZHANG
;
Cai-Yun ZHAO
;
Yuan L(U)
Author Information
1. 北京大学第一医院临床药理研究所
- Keywords:
average bioequivalence;
sample size;
power
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(22):2291-2294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the results of sample size and power calculated with different methods.Methods Several methods used for the determination of sample size and power in the assessing the bioequivalence of average bioavailability were provided,their principles were introduced,and examples were demonstrated.Results Different estimation methods gave similar results.Conclusion Methods by looking up tables and abbreviated calculation are easy and quick to use,and can satisfy majority of the task requirements.Exact calculation of sample size and power can only be accomplished by using the programs provided.Detailed tables with sample size and power at different situations are provided for reference.
