Correlation between NUDT1 genetic polymirphisms and purine-induced leukopenia
10.13699/j.cnki.1001-6821.2017.22.012
- VernacularTitle:核苷二磷酸链接部分X型结构域基因1基因多态性与嘌呤类药物所致白细胞减少症的相关性
- Author:
Hong ZHENG
1
;
Kang CHAO
;
Xia ZHU
;
Xiang GAO
;
Min ZHI
;
Pin-Jin HU
;
Min HUANG
;
Xue-Ding WANG
Author Information
1. 中山大学药学院临床药理研究所
- Keywords:
polymorphism;
leukopenia;
purine drug
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(22):2254-2256,2261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between nudix hydrolase 1 (NUDT1) polymorphism and the purine-induced leukopenia.Methods A total of 176 patients with Crohn's disease were enrolled.NUDT1 rs3735092 and rs34996498 were detected using Sequenom (R) Massarray matrix-assisted laser desorption/ionization-time of flight platform.The association between different genotypes and the purine-induced leukopenia was been analysed.Results NUDT1 rs34996498 (A ＞ G) was significantly associated with the purine-induced leukopenia (P ＜0.05),and this mutation showed marginal effect after Bonferroni correction.The mutation of NUDT1 rs3735092 (C ＞ T) was not associated with the purine-induced leukopenia (P ＞ 0.05).We found female had significant higher risk of the purine-induced leukopenia than male (P ＜0.01).Conclusion NUDT1 rs34996498 polymorphism might influence the purine-induced leukopenia and further study with larger sample size was warranted.
