Clinical trial of levetiracetam tablets in the treatment of children's intractable epilepsy
10.13699/j.cnki.1001-6821.2017.22.010
- VernacularTitle:左乙拉西坦片治疗儿童难治性癫痫的临床研究
- Author:
Hong-Ping TANG
1
;
Ming-Hui WANG
;
Ai JIAN
;
Pei ZENG
;
Tie FANG
;
Zi-Xing XIE
;
Jin-Shan XU
;
Li-Li ZHENG
;
Wen-Na MA
;
Fang FANG
Author Information
1. 常德市第一人民医院小儿内科
- Keywords:
levetiracetam tablet;
carbamazepine tablet;
children's intractable epilepsy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(22):2247-2249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy and safety of levetiracetam tablet and carbamazepine tablet in the treatment of children's intractable epilepsy.Methods A total of 96 children with intractable epilepsy were randomly divided into control group and treatment group with 48 cases per group.Control group was given carbamazepine 4-8 mg · kg-1 · d-1,tid,oral.Treatment group was given levetiracetam 4 mg · kg-1,bid,the maximum dose was 16 mg · kg-1 at the speed as 4 mg · kg-1 with every 2 weeks.Two groups were treated for 8 months.The clinical efficacy,neurocognitive function test [verbal intelligence quotient(VIQ),performance intelligence quotient (PIQ),total intelligence quotient(TIQ) and short-term visual memory],and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 87.50％ (42 cases/48 cases) and 79.17％ (38 cases/48 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:VIQ were (106.97 ± 5.65) and (95.25 ± 3.28) points,PIQ were (116.45 ± 5.16) and (103.61 ± 2.74) points,TIQ were(119.92 ± 4.69) and(95.20 ± 3.24) points,short-term visual memory were (18.45 ± 2.17) and (13.84 ± 1.81) s,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions of two groups were based on emotional,drowsiness,palpitations and dizziness,also,the incidences of adverse drug reactions in treatment and control groups were 12.50％ and 16.67％ without significant difference (P ＞ 0.05).Conclusion Levetiracetam tablet has a definitive clinical efficacy in the treatment of children's intractable epilepsy,which is better than carbamazepine tablet.Levetiracetam tablet can improve the cognitive ability for children's intractable epilepsy,without increasing the incidence of adverse drug reactions.
