Clinical trial of tiotropium bromide powder inhalation combined with theophylline sustained-release tablets in the treatment of chronic obstructive pulmonary disease in stable phase
10.13699/j.cnki.1001-6821.2017.22.006
- VernacularTitle:噻托溴铵粉吸入剂联合茶碱缓释片治疗稳定期慢性阻塞性肺疾病的临床研究
- Author:
Feng JIANG
1
;
Hong-Fei ZHENG
;
Ya-Jun LIU
;
Lin-Ying YANG
;
Gui-Fen PANG
;
Jin-Ling LI
;
Qing ZHANG
Author Information
1. 承德医学院附属医院呼吸内科
- Keywords:
theophylline sustained-release tablet;
tiotropium bromide powder inhalation;
chronic obstructive pulmonary disease;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(22):2233-2235,2238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of the tiotropium bromide powder inhalation combined with theophylline sustained-release tablets in the treatment of chronic obstructive pulmonary disease(COPD) in stable phase.Methods Forty patients of COPD in stable phase were randomly divided into control group and treatment group with 20 cases per group.Control group was given theophylline sustained-release tablets 0.2 g,bid,oral.Treatment group was given tiotropium bromide powder inhalation 18 μg,qd,Inhalation therapy.The clinical efficacy,mean blood oxygen saturation at nigh (MSaO2),lowest blood oxygen saturation (LSaO2),the ratio on the blood oxygen saturation ＜ 90％ of the total amount of sleep time (T90) and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in the treatment and control groups were 95.00％ (19 cases/20 cases)and 65.00％ (13 cases/20 cases) with statistically significant difference (P ＜ 0.05).After treatment,the main indexes in the treatment and control groups were compared:MSaO2 were (93.72 ± 3.44) ％ and (86.42 ± 4.11) ％,LSaO2 were (92.53 ±5.64)％ and(86.94 ±6.23)％,T90 were(28.14 ±6.31)％ and(31.22 ±7.81)％,the differences were statistically significant(all P ＜0.05).The adverse drug reactions in treatment group were based on dry mouth,which in control group were based on mild stomach discomfort.The incidences of adverse drug reaction in the treatment and control groups were 10.00％ and 5.00％ without significant difference(P ＞ 0.05).Conclusion Tiotropium bromide powder inhalation combined with theophylline sustained-release tablet has a definitive clinical efficacy and safety in the treatment of COPD in stable phase,which can improve the respiratory function.
