Progress in lysosome: key regulator of autophagy in lipid loaded cells
10.13699/j.cnki.1001-6821.2017.21.031
- VernacularTitle:溶酶体决定荷脂细胞的自噬流研究进展
- Author:
Bao-Xue AO
1
;
Neng ZHU
;
Chan LIU
;
Zhi-Zhong XIE
;
Duan-Fang LIAO
;
Li QIN
Author Information
1. 南华大学药物药理研究所
- Keywords:
lipid loaded cell;
atherosclerosis;
autophagy;
lysosome;
reverse cholesterol transport
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(21):2206-2208
- CountryChina
- Language:Chinese
-
Abstract:
The capacity of reverse cholesterol transport (RCT) of lipid loaded cells is critical of atherosclerosis(AS) development.Autophagy is an important regulatory mechanism promoting RCT.But the exact effects of autophagy activation or inhibition on RCT remain unclear in AS.So in this review we suggest that partly inhibition of autophagy or induction of lysosomal biogenesis improves the autophagy capacity of lipid loaded cells.
