Clinical trial of naloxone injection combined with aminophylline injection in the treatment of acute respiratory failure in children
10.13699/j.cnki.1001-6821.2017.21.005
- VernacularTitle:纳洛酮注射液联合氨茶碱注射液治疗小儿急性呼吸衰竭的临床研究
- Author:
You-Fen CHEN
1
;
Gang-Xi LIN
;
Zhu-Lan LIAN
Author Information
1. 厦门大学附属第一医院儿科
- Keywords:
naloxone;
aminophylline;
acute respiratory failure in children;
blood gas index
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(21):2107-2109,2116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of naloxone combined with aminophylline in the treatment of acute respiratory failure in children.Methods A total of 120 children with acute respiratory failure were randomly divided into the control group and the treatment group,with 60 cases in each group.The control group was given conventional treatment (3 mg nikethamide + 500 mL of normal saline or 5％ glucose solution for intravenous infusion,50 mL · h-1,bid).The treatment group was additionally treated with intravenous injection of naloxone 0.01 ～ 0.05 mg kg-1 combined with aminophylline 4 ～8 mg,50 mL · h-1,bid,on the basis of the control group.Both groups were treated for 7 d.The clinical efficacy,blood gas parameters before and after treatment and the incidence of adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates of the treatment group and the control group were 85.00％ (51 cases/60 cases) and 66.67％ (40 cases/60 cases),respectively (P ＜ 0.05).After treatment,there were significant differences between the treatment group and the control group in the power of hydrogen (pH) [(7.01 ±0.06) vs (7.11 ±0.29)],arterial partial pressure of oxygen (PaO2) [(68.99 ± 11.44) vs (59.34 ± 10.30) mmHg],arterial partial pressure of carbon dioxide (PaCO2) [(63.24 ± 10.54) vs (70.69 ± 18.98) mmHg],arterial oxygen saturation (SaO2) [(85.57 ± 13.79) vs (69.01 ± 10.03) mmHg] and the ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) [(40.43 ± 12.47)％ vs (35.07 ± 11.83)％] (P ＜0.05).The adverse drug reactions of the treatment group mainly included rash,vomiting and convulsions while adverse drug reactions of the control group mainly included rash,vomiting,convulsions and arrhythmia.The incidence rates of adverse drug reactions in the treatment group and the control group were 11.67％ (7 cases/60 cases) and 26.67％ (16 cases/60 cases),respectively (P ＜0.05).Conclusion Naloxone combined with aminophylline exerted considerable clinical efficacy with high safety profile in the treatment of acute respiratory failure in children.
