Analysis of the efficacy of cinepazide maleate injection on acute cerebral ischemic stroke
10.13699/j.cnki.1001-6821.2017.20.024
- VernacularTitle:马来酸桂哌齐特注射剂治疗急性缺血性脑卒中有效性的分析
- Author:
Si-Yuan ZHU
1
;
Ying-Ying YAN
;
Zhan-Miao YI
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
cinepazide maleate injection;
acute cerebral ischemic stroke;
Meta-analysis;
efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(20):2081-2083,2088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the efficacy of cinepazide maleate injection in the treatment of the acute Cerebral Ischemic Stroke.Methods We searched the PubMed,EmBase,Cochrane Central Register of Controlled Trials,Clinical Trials,CNKI,Wanfang Database,VIP and Chinese Bio-Medicine Database from established to Sept.2016.We used RevMan 5.3 software to perform Meta-analysis of National Institute of Health Stroke Scale (NIHSS) score improvement and response rate.The intervention measures of the treatment group were cinepazide maleate injection with basic treatment while which of the control group are basic treatment with placebo,with western medicine injections or with traditional Chinese medicine injections.Results Twenty randomized controlled trials involving 2237 patients were included.The results of meta-analyses:The NIHSS score of treatment group decreased 2.73 more than the control group.The response rate of the treatment group was 1.22 times higher than that of control group.The differences were statistically significant (all P ＜0.01).Conclusion Cinepazide maleate injection has good efficacy which could decrease the NIHSS score and response rate.
