Clinical trial of low molecular weight heparin combined with active immunotherapy in the treatment of recurrent spontaneous abortion
10.13699/j.cnki.1001-6821.2017.20.007
- VernacularTitle:低分子肝素联合主动免疫治疗复发性自然流产的临床研究
- Author:
Zhi-Qiang YAN
1
;
Chun-Ling YU
;
Pei-Hui MO
;
Mei TANG
;
Ai-Zhen FU
Author Information
1. 儋州市第一人民医院妇产科
- Keywords:
low molecular weight heparin;
active immunization;
recurrent spontaneous abortion;
hemodynamics
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(20):2020-2022,2050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of low molecular weight heparin combined with active immunization on patients with recurrent spontaneous abortion and its influences of hemodynamics.Methods A total of 92 cases of recurrent spontaneous abortion patients were randomly divided into treatment group (46 cases) and control group (46 cases).In control group,the lymphocytes of the patients' husbands were actively immunized.After pregnancy confirmed with blood β-human chorionic gonadotropin (β-HCG),the patients were administered of progesterone 40 mg,intramuscularly once a day until 14 weeks of gestation.The treatment group was treated with low molecular heparin calcium 5000 U,twice a day on the basis of control group until 24 h before termination of pregnancy.The clinical efficacy,the levels of β-HCG,progesterone and hemodynamics and the incidence of adverse drug reactions were observed before and after treatment.Results The clinical effective rate in treatment group was 95.65％ (44 cases/46 cases),had significant difference with that in control group,which was 76.09％ (35 cases/46 cases,P ＜0.05).After treatment,the levels of β-HCG in treatment group and control group were (6535.05 ± 54.34),(9845.50 ± 86.91) mU · mL-1,progesterone were (123.45 ±3.79),(93.24 ±5.18) nmol · L-1 (all P ＜0.05).After treatment,the blood viscosity,whole blood low shear viscosity and plasma viscosity in treatment group were (5.98 ± 0.52),(7.68 ± 0.51),(1.90 ± 0.34) mPa · s,had significant difference with those in control group,which were (7.78 ± 0.76),(9.18 ± 0.71),(2.30 ± 0.29) mPa · s (all P ＜ 0.05).In treatment group,there were 3 cases of erythema and itching in the injection site,2 cases of temporary vaginal bleeding,the incidence of adverse drug reactions was 10.87％ (5 cases/46 cases).There were 4 cases of erythema and itching in the injection site in control group,with incidence of 8.70％ (4cases/46 cases,P ＞ 0.05).Conclusion Low molecular weight heparin combined with active immunization has a significant effect on recurrent spontaneous abortion,and can improve the blood rheology.
