Clinical trial of Xinshuning capsules combined with rehabilitation training in the treatment of chronic heart failure
10.13699/j.cnki.1001-6821.2017.20.003
- VernacularTitle:心舒宁胶囊联合康复训练治疗老年慢性心力衰竭的临床研究
- Author:
Jin MA
1
;
Yan ZHANG
;
Wei-Na PEI
Author Information
1. 辽宁医药职业学院康复教研室
- Keywords:
Xinshuning capsule;
rehabilitation training;
chronic heart failure;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(20):2005-2008
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of Xinshuning capsules combined with rehabilitation training in the treatment of chronic heart failure.Methods A total of 99 patients with chronic heart failure were randomly divided into control group (n =46 cases) and treatment group (n =53 cases).Control group received the rehabilitation training.Treatment group was given Xinshuning capsules 2.0-3.2 g,tid,oral,on the basis of control group.Two groups were treated for 8 weeks.The clinical efficacy,cardiac function and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates in treatment and control groups were 90.57％ (48 cases/53 cases) and 71.74％ (33 cases/46 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:left ventricular end systolic diameter were (31.94 ±4.68),(38.85 ±4.01)mm;left ventricular end diastolic diameter were (47.21 ± 7.81),(54.58--± 7.75) mm;left ventricular mass indexes were (58.84 ± 4.73) (52.37 ± 5.01) g · m-2;;left ventricular ejection fraction were (49.91 ± 6.95) ％,(44.23 ± 5.29) ％;left atrial diameter were (34.34 ± 6.27),(40.32 ± 6.52) mm,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in two groups were based on headache,gastrointestinal reactions,and rash.The incidences of adverse drug reactions in treatment and control groups were 5.66％ and 10.87％ without significant difference (P ＞ 0.05).Conclusion Xinshuning capsules combined with rehabilitation training have a definitive clinical efficacy in the treatment of chronic heart failure,which can improve the heart function,without increasing the incidence of adverse drug reactions.
