Clinical trial of taurine tablets in the treatment of acute respiratory distress syndrome
10.13699/j.cnki.1001-6821.2017.20.001
- VernacularTitle:牛磺酸片治疗急性呼吸窘迫综合征的临床研究
- Author:
Liang CHEN
1
;
Zi-Li MENG
;
Yong-Qing HONG
;
Rong ZHU
Author Information
1. 淮安市第一人民医院呼吸科
- Keywords:
taurine;
acute respiratory distress syndrome;
arterial oxygen tension;
von Willebrand factor;
soluble intercellular cell adhesion molecule
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(20):1999-2001
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety profile of taurine tablets in the treatment of acute respiratory distress syndrome (ARDS).Methods One hundred patients with ARDS were randomly divided into control group (n =50 cases) and treatment group (n =50 cases).Both groups were given conventional treatments,such as mechanical ventilation,liquid management.The treatment group was treated with taurine tablets 60 mg · kg-1 · d-1,while the control group was given the same amount of placebo.Both groups were treated for 7 d.The clinical efficacy,oxygenation index,yon Willebrand factor (vWF),soluble intercellular adhesion factor-1 (sICAM-1),and the incidence of adverse drug reactions were observed in the two groups.Results After treatment,the effective rate of the treatment group and the control group was 66.00％ (33 cases/50 cases) and 24.00％ (12 cases/50 cases),the difference was statistically significant (P ＜ 0.05).After treatment,oxygenation index of the treatment group and the control group were (289.51 ± 67.63) and (213.49 ± 63.67) mmHg,vWF were (167.71±40.38) and (194.79±46.57) mg · L-1,sICAM-1 were (387.93 ±200.46) and (499.11 ±218.12) mmHg,the differences were statistically significant(P ＜0.05).No adverse drug reactions were found in the 2 groups.Conclusion Taurine can effectively improve the state of patients with hypoxia and increase oxygenation index,as well as reduce the relevant inflammatory factors,thus it is effective in the treatment of acute respiratory distress syndrome.
