Current situation in individual administration of high dose methotrexate
10.13699/j.cnki.1001-6821.2017.19.040
- VernacularTitle:高剂量甲氨蝶呤个体化治疗研究现状
- Author:
Rui-Jin CUI
1
;
Rui-Juan XU
Author Information
1. 中国药科大学
- Keywords:
high-dose methotrexate;
individualized treatment;
plasma concentration;
genetic polymorphism
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1987-1989
- CountryChina
- Language:Chinese
-
Abstract:
High dose methotrexate is a cornerstone of therapy for acute lymphoblastic leukemia and osteosarcoma.However MTX levers exhibit significant inter-individual variability in clinical,and acute toxicity after high-does MTX is often unexpected,thus it needs individual administration.
