Advance in search for gene polymorphisms related to efficacy and adverse reactions of methotrexate
10.13699/j.cnki.1001-6821.2017.19.039
- VernacularTitle:基因多态性与甲氨蝶呤疗效和不良反应相关性的研究进展
- Author:
Ya-Nan CHU
1
;
Li-Ying FENG
;
Jie-Yu ZHANG
;
Xue-Jiao LIU
Author Information
1. 中国人民解放军南京总医院药理科
- Keywords:
methotrexate;
gene polymorphism;
metabolism;
transport;
target
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1982-1986
- CountryChina
- Language:Chinese
-
Abstract:
In clinical practice,methotrexate exhibits individual difference in drug efficacy and adverse reactions.Genetic variation is one of the most important influence factors.The article reviewed latest researches of methotrexate in metabolism,transport,and targets to discover the relationship between gene polymorphisms on pharmacogenomics and methotrexate so as to provide references for clinical individualized treatment.
