Relaxed effect of Cynomorium songaricum Rupr and its active ingredients on detrusor muscle strip tension in rats
10.13699/j.cnki.1001-6821.2017.19.025
- VernacularTitle:锁阳提取物及其活性成分对大鼠膀胱逼尿肌紧张的舒张作用
- Author:
Xiao-Ting YUN
1
;
Zhi-Qian WANG
;
Wen-Zhang ZHOU
;
Er-Wei LIU
;
Rui TAO
;
Lin MIAO
;
Chan-Yuan JIAO
;
Xue-Ni WANG
Author Information
1. 天津中医药大学天津市现代中药重点实验室方剂学教育部重点实验室
- Keywords:
Cynomorium songaricum Rupr;
benign prostatic hyperplasia;
lower urinary tract symptom;
detrusor muscle strip
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1938-1941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relaxed effect of Cynomorium songaricum Rupr (CS) on the detrusor muscle strip tension in rats.Methods Detrusor muscle strips of rats were isolated.The effects of the CS extract and its active ingredients on the potassium chloride (KCl) or acetylcholine (Ach) induced-contraction of detrusor muscle strip were investigated in vitro respectively.Results Both KCl and Achsignificantly induced spontaneous contraction of bladder detrusor muscle strips,and CS extract inhibited both KCl and Ach-induced contraction in a dose-dependent manner.The maximum relaxation ratios of CS in response to KCl and Ach were (23.34 ± 2.40) ％ and (25.42 ± 5.53) ％ respectively at the concentration of 1 × 10-2g · mL-1.Its active ingredient Luteolin (LUT),Epicatechin (EPI) and Epigallocatechin gallate (ECG) also inhibited KCl-induced contraction of bladder detrusor muscle strips,and the relaxation ratios were (19.31 ±7.19)％,(19.03 ±6.86)％ and (21.22 ± 10.89) ％,respectively.Conclusion CS could relieve detrusor tension in bladder,in which LUT,EPI and ECG are involved.
