Effects of propofol injection and digoxin injection on postoperative recovery period agitation and postoperative pain in patients undergoing general anesthesia
10.13699/j.cnki.1001-6821.2017.19.015
- VernacularTitle:丙泊酚注射液与地佐辛注射液对全麻下手术患者术后苏醒期躁动及术后镇痛的影响
- Author:
Wen YU
1
Author Information
1. 复旦大学附属华山医院北院麻醉科
- Keywords:
propofol injection;
ventani injection;
dezocine injection;
emergence agitation;
postoperative pain
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1903-1905
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of propofol combined with dezocine on postoperative recovery period agitation and postoperative pain in patients with operation under general anesthesia.Methods A total of 52 patients with operation under general anesthesia were randomly divided into control group and treatment group,26 cases in each group.At 15 min before the end of operation,control group was given dezocine 0.15 mg · kg-1 + fentanyl 0.6 μg · kg-1,intravenous injection.Treatment group was treated with dezocine 0.15 mg · kg-1 + propofol 2.0 mg · kg-1,intravenous injection.Postoperative eye opening time,extubation time,extubation of mean arterial pressure (MAP),heart rate (HR),sedation,pain score and safety were compared between the two groups.Results After surgery,eye opening times in control group and treatment group were (13.28 ± 0.63),(9.21 ± 0.37) min.Extubation times in control group and treatment group were (17.23 ± 1.14),(13.74 ± 1.02) min.The MAP in control group and treatment group were (97.64 ±9.34),(90.13 ± 7.32)mmHg.The HR in control group and treatment group were (86.34 ± 5.27),(78.46 ± 6.47) time · min-1,with significant difference (all P ＜ 0.05).The sedation-agitation scales (SAS) in control group and treatment group were 5.03 ± 0.45,3.49 ± 0.17.The visual analogue scales (VAS) in control group and treatment group were 4.23 ± 0.24,2.11 ± 0.16,with significant difference (all P ＜ 0.05).In control group,adverse drug reactions were dizziness,nausea and vomiting,the incidence of adverse drug reactions was 11.54％ (3/26 cases).The adverse drug reactions in treatment group were nausea,vomiting,hypotension and adverse drug reactions was 7.69％ (2/26 cases),with no significant difference (P ＞ 0.05).Conclusion Compared with fentanyl and dezocine,the propofol and dezocine can significantly reduce the degree of postoperative recovery period agitation and pain after operation in patients with operation under general anesthesia,stable extubation MAP and HR,and do not prolong the time of awakening and extubation,and the safety was high.
