Expressions of Caveolin-1 and Ki-67 in esophageal squamous cell carcinoma tissues and its clinical significance
10.13699/j.cnki.1001-6821.2017.19.011
- VernacularTitle:小凹蛋白-1和Ki-67在食管鳞癌中的表达及临床意义
- Author:
Yu-Hong FAN
1
;
Hai-Feng ZHOU
;
Zhan-Fu HOU
;
Xue-Liang WU
;
Li-Kun WANG
;
Ya-Xiong HOU
Author Information
1. 河北北方学院附属第一医院病理生理教研室
- Keywords:
esophageal squamous cell carcinoma;
Caveolin-1;
proliferating antigen;
immunohistochemistry
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1889-1892
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of Caveolin-1 and Ki-67 in esophageal squamous cell carcinoma tissues and discuss the clinical significances.Methods The expressions of Caveolin-1 and Ki-67 in 110 specimens of esophageal squamous cell carcinoma tissues (treatment group) and 15 specimens of normal esophageal tissues (control group) were detected by immunohistochemistry technique.The correlation between their positive expression and the elinieopathologie features were analyzed.Results The positive rates of Caveolin-1 were 47.62％ (10/21 cases),70.91％ (39/55 cases),94.11％ (32/34 cases) in low,middle,and high differentiation in treatment group,had significant difference with that in control group,which was 33.33％ (5/15 cases,P ＜ 0.05).The positive rates of Ki-67 were 52.38％ (11/21 cases),85.45％ (47/55 cases),97.06％ (33/34 cases) in low,middle,and high differentiation in treatment group,had significant difference with that in control group,which was 20.00％ (3/15 cases,P ＜0.05).Expression of Caveolin-1 was positively related with expression of Ki-67 in esophageal squamous cell carcinoma tissues(r =0.545,P ＜ 0.001).The positive expression of Caveolin-1 and Ki-67 were correlated with differentiation degree,tumor-node-metastasis (TNM) stage,lymph node metastasis,and liver metastasis(all P ＜0.05).Conclusions The expression levels of Caveolin-1 and Ki-67 are high in esophageal squamous cell carcinoma tissues,which have correlation with differentiation degree,TNM stage,lymph node metastasis,and liver metastasis.
