Influences of ABCB1 polymorphism on the dose adjusted blood concentration of tacrolimus and renal function in renal transplant recipients with cytochrome P450 3A5 * 3/* 3 genotype
10.13699/j.cnki.1001-6821.2017.19.007
- VernacularTitle:ABCB1多态性对细胞色素P450 3A5*3/*3肾移植受者他克莫司剂量调整血药浓度及肾功能的影响
- Author:
Duo-Ling MA
1
;
Yun-Yun YANG
;
Wen-Wen ZHANG
;
Yi-Ming HUA
;
Yan-Fang BIAN
;
Zhen CAI
;
Zhuo WANG
;
Xue-Bin WANG
Author Information
1. 上海长海医院药学部
- Keywords:
renal transplantation;
tacrolimus;
serum creatinine
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1874-1877
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ABCB1 genetic polymorphism on the dose(D) adjusted blood concentration(C/D) of tacrolimus (TAC) and renal function in renal transplant recipients with cytochrome P450 3A5 * 3/* 3 (CYP3A5 * 3/* 3) genotype during the stable period.Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to detect CYP3A5 * 3 and ABCB1 genotypes;allele,genotype frequencies and Hardy-weinberg equilibrium were analysed by SHEsis software.The effects of ABCB1 polymorphism on the C/D of TAC and serum creatinine (Scr) were analyzed using SPSS 18.0 software.Results For renal transplant recipients with CYP3A5 * 3/* 3 genotype,the C/D of tacrolimus in CC genotype of ABCB1 C1236T were significantly lower than that of CT + TT genotypes (P ＜ 0.05).The Scr of GG + GA + AA + GT + AT genotypes of ABCB1 G (A) 2677T were significantly lower than that of TT genotype (P ＜ 0.05).The Scr of CC + CT genotypes of ABCB1C3435T were significantly lower than that of TT genotype (P ＜ 0.05).Conclusion ABCB1 C1236T polymorphism has an effect on the C/D of tacrolimus in renal transplant recipients with CYP3A5 * 3/* 3 genotype during the stable period.Both ABCB1 G (A) 2677T and C3435T polymorphism influence the renal function of those transplant recipients.
