Clinical trial of hydrotalcite tablets combined with esomeprazole magnesium enteric-coated tablets in the treatment of active gastric ulcer with Helicobacter pylori infection
10.13699/j.cnki.1001-6821.2017.19.005
- VernacularTitle:铝碳酸镁片联合埃索美拉唑肠溶片治疗幽门螺杆菌感染合并活动性胃溃疡的临床研究
- Author:
Ren-Xu LAI
1
;
Jiang-Nan REN
;
Xin-Min GOU
;
Min-Zhao GAO
;
Lei MAI
;
Hui-Xue GUO
Author Information
1. 中山大学附属第五医院消化内科
- Keywords:
hydrotalcite tablet;
esomeprazole magnesium enteric-coated tablet;
Helicobacter pylori;
active gastric ulcer
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1868-1870
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of hydrotalcite tablets combined with esomeprazole magnesium enteric-coated tablets in the treatment of active gastric ulcer with Helicobacter pylori (Hp) infection.Methods A total of 87 cases of active gastric ulcer with Hp infection were randomly divided into control group (n =44 cases) and treatment group (n =43 cases).Control group was treated with esomeprazole enteric coated tablet 20 mg,qd,orally.Treatment group was given hydrotalcite tablets 1 g each time,tid,orally.The two groups were treated for 4 weeks.The clinical efficacy,Hp eradication rate,healing quality and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 90.70％ (39/43 cases) and 88.64％ (39/44 cases),the eradication rates of Hp were 81.40％ (35/43 cases) and 77.27％ (34/44 cases),there were no significant differences (all P ＞ 0.05).After treatment,the healing quality of treatment group and control group (grade) were 65.12％ (28/43 cases) and 40.91％ (18/44 cases) with significant difference (P ＜ 0.05).The adverse drug reactions in the treatment group were based on anorexia,dizziness and nausea,which in control group were based on lack of appetite and nausea.The incidences of adverse drug reactions in treatment and control groups were 13.95 ％ and 11.36％ without significant difference (P ＞ 0.05).Conclusion There were the same clinical efficacy and safety in the treatment of active gastric ulcer with Hp infection between hydrotalcite tablet combined with esomeprazole enteric coated tablet and single use of esomeprazole magnesium enteric-coated tablet,but the former can significantly improve the quality of ulcer healing.
