Clinical trial of aerosolized in halation of salbutamol suspension in the treatment of children with asthma
10.13699/j.cnki.1001-6821.2017.19.002
- VernacularTitle:雾化吸入沙丁胺醇混悬液治疗哮喘患儿的临床研究
- Author:
Min LI
1
;
Yu TANG
;
Er-Yao ZHAO
;
Lei ZHANG
;
Chao-Hui CHEN
;
Jun-Ying QIAO
Author Information
1. 郑州市儿童医院东区呼吸科
- Keywords:
glucocorticoid;
salbutamol;
asthma;
eosinophil;
immunoglobulin E;
lung function
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(19):1858-1861
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of aerosolized inhalation of salbutamol suspension in the treatment of children with asthma and the influence of lung function,blood eosinophil (EOS) and immunoglobulin E(IgE).Methods A total of 160 children with asthma were randomly divided into treatment group (n =80 cases) and control group (n =80 cases).The control group was treated with inhaled budesonide 1.0 mg,5 min a time,twice a day,while the children in treatment group were treated combined with salbutamol 5 minutes a time,twice a day on the basis of control group.All patients were treated for 2 weeks.The clinical efficacy in two groups were observed.The changes of blood EOS and IgE at 3 months after treatment were observed.Results The total effective rate in treatment group was 98.68％ (75/76 cases),had significant difference with that in control group,which was 84.13％ (53/63 cases,P ＜ 0.05).And 3 months after treatment,the forced vital capacity (FVC),forced expiratory volume in first second(FEV1),peak expiratory flow (PEF),vital capacity(VC) in treatment group were (79.34 ± 6.52) L,(80.12 ± 3.32) L,(82.08 ±9.62) L· min-1,(83.42 ±4.10) L,had significant difference with those in control group,which were (70.20±3.34)L,(68.25 ±2.90)L,(71.21 ±4.52) L · min-1,(73.17 ±2.34) L (all P＜0.05).The absolute value of EOS and IgE in treatment group were (0.52 ± 0.13) × 109/L,(105.32 ± 62.35) ng · mL-1,had significant difference with those in control group,which were (0.96 ± 0.23) × 109/L,(222.58 ± 84.71) ng · mL-1(all P ＜ 0.05).The control group occurred 1 cases (1.59％) of nausea,while treatment group occurred 2 cases(2.63％) of hoarseness,with no significant difference (P ＞ 0.05).No drug allergy,nosocomial infections,rash and other adverse reactions occurred in two groups.Conclusion The application of glucocorticoid combined with salbutamol inhalation has significant effect on children with asthma,and can significantly reduce the levels of EOS and IgE in blood,and improve lung function.
