Research progress on pharmacological actions of gingerols in cardiovasular disease
10.13699/j.cnki.1001-6821.2017.18.026
- VernacularTitle:姜酚在心血管疾病中的药理作用研究进展
- Author:
Ying-Zhi WU
1
;
Qiang FU
;
Quan-Neng YAN
;
Zhi-Liang LI
Author Information
1. 南方医科大学珠江医院心血管内科
- Keywords:
gingerols;
anti-oxidative;
anti-hypertensive;
anti-platelet;
anti-atherosclerosis
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(18):1824-1827
- CountryChina
- Language:Chinese
-
Abstract:
Gingerols are the important active compounds in ginger(Zingiber ocinale Roscoe,Zingiberacae),and 6-gingerol is the main compound of gingerols.Chinese and foreign scholars have done a lot of studies on the molecular structure and pharmacological effects of gingerols and its homologues,which confirmed that gingerols have cardiovascular pharmacological effects of anti-inflammatory,anti-oxidative,anti-hypertensive,cardiac,anti-platelet,hypolipidemic,anti-atherosclerosis and so on.Gingerols play the above pharmacological effects by inhibiting the inflammatory factors,angiotensin Ⅱ activity,cyclooxygenase activity,thromboxane synthesis,the production of advanced glycation end-products;promoting the activity of myocardial sarcoplasmic reticulum Ca2+-ATPase;regulating relate enzyme expression during the process of lipid metabolism and other ways.This article mainly reviews the recent progress in the pharmacological mechanism of gingerols in cardiovascular diseases.
