Analysis of influence factors on tacrolimus concentration in patients with nephrotic syndrome
10.13699/j.cnki.1001-6821.2017.18.022
- VernacularTitle:肾病综合征患者他克莫司血药浓度影响因素分析
- Author:
Xu ZHU
1
;
Tong LU
;
Zi-Wei YIN
;
Li-Min LIU
;
Lu PANG
;
Li-Mei ZHAO
Author Information
1. 中国医科大学附属盛京医院药学部
- Keywords:
tacrolimus;
blood concentration;
influence factor;
nephrotic syndrome
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(18):1810-1812,1816
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate influence factors of tacrolimus blood concentration,and provide reference for the clinical use of tacrolimus by analyzing tacrolimus blood concentrationin patients with nephrotic syndrome.Methods Data of tacrolimus usage were retrospectively collected from August 2015 to July 2016 in 114 patients with nephrotic syndrome in our hospital.Association of dose,age,sex,drug combination,blood routine index,hepatic and kidney function index with tacrolimus blood concentrations were analyzed.Results Tacrolimus concentration in the effective range of patients was 48.25％.Dose of female group was significantly higher than that in male group (P ＜ 0.05),while dose -adjusted concentration of female group was significantly lower than that of male group (P ＜ 0.05).There was significant difference in the proportion of combined Wuzhi tablet among different concentration groups (P ＜ 0.05).Conclusion Sex and combination with Wuzhi tablet could significantly affect tacrolimus concentration.Physicians and clinical pharmacists should follow the principle of individualized medicine,formulate and adjust drug regimen according to the influence factors of tacrolimus concentration.
