Clinical trial of flurbiprofen axetil injection in the treatment of elderly hip replacement with preemptive analgesia
10.13699/j.cnki.1001-6821.2017.18.011
- VernacularTitle:氟比洛芬酯注射液用于老年髋关节置换术患者超前镇痛的临床研究
- Author:
Xue-Feng DENG
1
Author Information
1. 安徽中医药大学第一附属医院麻醉科
- Keywords:
flurbiprofen acetate injection;
hip replacement;
cognitive function;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(18):1771-1772,1784
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of different concentrations of flurbiprofen axetil injection in the treatment of elderly hip replacement with preemptive analgesia.Methods Fifty patients with elderly hip replacement were randomly divided into control group and treatment group with 25 cases per group.Control group was given 1.0 mg · kg-1 flurbiprofen axetil,intravenous infusion.Treatment group was given 5.0 mg· kg-1 flurbiprofen axetil,intravenous infusion.The mini-mental state examination (MMSE) scale scores and adverse drug reactions were compared between two groups.Results After operation 12,24 h,the MMSE scores in treatment group were (29.30 ± 2.05) and (31.09 ±5.32) points,which in the control group were (25.14 ± 1.42) and (26.50 ±0.53) points,the differences were statistically significant between two groups (all P ＜ 0.05).The adverse drug reactions in the treatment group were based on vomiting and restlessness,which in the control group were based on restlessness,fatigue,vomiting and respiratory inhibition.The incidences of adverse drug reactions in treatment and control groups were 12.00％ and 40.00％ with significant difference (P ＜ 0.05).Conclusion 5.0 mg · kg-1 flurbiprofen axetil injection has a definitive and safety in the treatment of elderly hip replacement with preemptive analgesia.
