Clinical trial of atorvastatin calcium tablets in the treatment of nontraumatic subdural hematoma
10.13699/j.cnki.1001-6821.2017.18.005
- VernacularTitle:阿托伐他汀钙片治疗非创伤性硬膜下血肿的临床研究
- Author:
Kai-Hua YANG
1
;
Yun-Hu YU
;
Qi-Shan RAN
;
Yuan-Chao WEN
;
Hang LI
;
Xiao-Hong FU
Author Information
1. 遵义医学院第三附属医院神经外科
- Keywords:
atorvastatin calcium tablet;
nontraumatic subdural hematoma;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(18):1751-1753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of atorvastatin calcium tablets in the treatment of nontraumatic subdural hematoma.Methods A total of 52 patients with nontraumatic subdural hematoma were randomly divided into control group and treatment group with 26 cases per group.Control group was given the treatment of drilling and drainage for 2-3 days.Treatment group received atorvastatin calcium 20 mg,qd,oral for 28 days,on the basis of control group.The clinical efficacy,serum superoxide dismutase (SOD),malondialdehyde (MDA),recurrence rate,and adverse drug reaction were compared between the two groups.Results After treatment,the total effective rates in treatment and control groups were 84.62％ (22/26 cases) and 57.69％ (15/26 cases) with significant difference (P ＜0.05).After treatment,the SOD in control and treatment groups were (115.29 ±13.34),(128.39±14.29) U·mL-1;MDA were (19.83 ±2.43),(15.40 ± 1.67) nmol · mL-1;recurrence rates were 26.92％ (7/26cases) and 0 (0/26 cases),the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in treatment group were based on increased hematoma volume and infection,which in control group were based on intracranial emphysema,increased hematoma volume,infection,abnormal liver function and brain damage.The incidences of adverse drug reactions in treatment and control groups were 7.69％ and 34.62％ with significant difference (P ＜ 0.05).Conclusion Atorvastatin calcium tablets have a definitive clinical efficacy and safety in the treatment of nontraumatic subdural hematoma.
