Advances in research for the organ-specific migration of mesenchymal stromal cells
10.13699/j.cnki.1001-6821.2017.17.030
- VernacularTitle:间充质干细胞组织特异性归巢的研究进展
- Author:
Yuan-Zhi LIU
1
;
Yi-Lan HUANG
;
Ji-Yin ZHOU
;
He-Jiao LI
;
Zuo ZHANG
Author Information
1. 西南医科大学药学院
- Keywords:
homing;
mesenchymal stem cell;
influencing factor;
cell tracking
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(17):1717-1720
- CountryChina
- Language:Chinese
-
Abstract:
As non-hematopoietic multipotent stem cells,mesenchymal stem cells (MSCs) with the potential of selfrenewal and multi-directional differentiation,play a key role in the process of tissue regenerations and anti-inflammation.In the case,the efficacy of these MSC-based therapies at least partly depends on specific homing towards the site where the cells are needed.Nowdays,many studies find that the different homing characteristics in different organizations,which limits the therapeutic efficacy when they are used in stem cell therapy.Thus,the homing phenomena,the therapeutical efficacy,the influencing factors and the cell tracing techniques of MSCs in bone marrow,spleen and lymph nodes,intestine,heart,cancer and multiple organ are reviewed in the article.
