Preparation of axitinib in biodegradable drug membranes for ocular surface
10.13699/j.cnki.1001-6821.2017.17.024
- VernacularTitle:阿西替尼眼用生物可降解药膜的制备
- Author:
Zhi-Shu BAO
1
;
Meng-Meng LUO
;
Feng DENG
;
Kai-Hui NAN
Author Information
1. 温州医科大学附属眼视光医院眼科
- Keywords:
axitinib;
composite film;
performance evaluation in vitro
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(17):1693-1696
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prolong the action time of the drug in the eye and enhance the therapeutic effect,axitinib composite film was prepared for ocular surface repair,anti-infection and inhibit comeal neovascularization.Methods Axitinib as a model,using cast film technology combined with calcium ion cross-linking technology to prepare drug-loaded composite membrane.Determination of drug content by high performance liquid chromatography (HPLC),detection of drug release in vitro.Results The composite film was transparent,the thickness was (85 ± 11) μm,the diameter of 200 μm diameter of axitinib drug carrier was (6.5 ± 0.8) μg/film.The drug-loaded films had good corneal dissolvability and histocompatibility.Conclusion After the initial process optimization,the successful preparation of axitinib eye composite film.Composite film has slow release function,greatly increasing the drug in the eye tissue retention time,clinical application prospects.
