Pharmacokinetic processes of adriamycin-heparinized mesoporous silica anticancer drug delivery system in rats
10.13699/j.cnki.1001-6821.2017.17.017
- VernacularTitle:阿霉素-肝素介孔硅抗癌药物系统在大鼠体内的药代动力学
- Author:
Yang GAO
1
;
Rui-Fang LI
;
Xiang-Jun QIU
;
Qiang WU
;
Long-Long WANG
;
Yan-Shuang QI
Author Information
1. 河南科技大学医学院药理学与分子生物学重点实验室
- Keywords:
adriamycin;
heparin;
mesoporous silica;
drug delivery;
pharmacokinetics
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(17):1668-1670
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacokinetic processes of adriamycin-heparinized mesoporous silica anticancer drug delivery system (AMS-HP) in rats.Methods Six male Sprague-Dawley rats were used.AMS-HP was administered intravenously via a sublingual vein with a dose of 8 mg · kg-1.Blood was sampled from the tail before treatment and 0,0.08,0.17,0.5,1,3,6,12,24,36,48,60,72 h after given drugs.The plasma concentration of adriamycin in AMS-HP was determined by HPLC.The pharmacokinetic parameters were determined by DAS 2.0 software.Results The main pharmacokinetic parameters of adriamycin in AMS-HP were as follows:Cmax,t1/2,tmax,V/F,CL/F,AUC0-t,AUC0-∞ were (5.71 ± 0.46) L · h-1 · kg-1,(15.81±2.01) h,(3.00 ±0.00) h,(140.12 ±17.87) L · kg-1,(118.74±18.04) ng · mL-1,(3599.96 ±881.99) ng · mL-1 · h,(3838.51 ± 817.60) ng · mL-1 · h,respectively.Conclusion The HPLC method of plasma concentration of adriamycin in AMS-HP is specific and has good accuracy,precision and high sensitivity.Adriamycin in AMS-HP has a long half-life and a slow release effect in vivo.
