Clinical trial and safety of highly active antiretroviral therapy in the treatment of human immunodeficiency virus patients
10.13699/j.cnki.1001-6821.2017.17.002
- VernacularTitle:高效抗逆转录病毒疗法治疗艾滋病患者的疗效与安全性
- Author:
Su-Mei CHEN
1
;
Yong-Nian LIN
;
Xiu-Hua HE
;
Jiang-Fu LIU
;
Ru-Yi GUO
;
Yi-Peng GAO
Author Information
1. 福建医科大学附属泉州第一医院感染科
- Keywords:
highly active antiretroviral therapy;
acquired immunodeficiency syndrome;
CD4-+ T lymphocyte count;
viral load
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(17):1618-1620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study application of highly active antiretroviral therapy (HAART) in the treatment of human immunodeficiency virus (AIDS) patients.Methods From June 2013 to January 2015,60 cases of AIDS patients in our hospital were researched,both were given HAART,all patients were taken lamivudine 0.3 g qd,zidovudine 0.3 g bid,efavirenz tablets 600 mg qn,1 time/day.Before and after treatment of 3 months,6 months,12 months,patients with CD4-+ T lymphocyte counts and HIV viral load changes were determined.The patient's clinical curative effect and adverse drugs reaction were analyzed.Results After 12 months treatment,the total effective rate was 93.33％ (56/60 cases).After 3 months treatment,among CD4-+ T lymphocyte count was significantly increased than before treatment [(144.64±6.47) vs (104.74 ±9.58) pcs · μL-1],viral load was significantly reduced than before treatment [(4.80 ± 0.20) vs (7.76 ±0.42) g · copies · mL-1),the difference had statistical significance (all P ＜ 0.05).There were 7 patients bone marrow suppression,5 cases had liver toxicity (occured in 1,2 months after treatment);3 cases with Ⅱ and peripheral neuritis (occured in 3,4,and 6 months after treatment).Conclusion HIV patients with HAART therapy has better effect of immunology and virology.
