Clinical trial of pyridostigmine combined with doxazosin mesylate in the treatment of elderly women with urinary retention after cervical cancer surgery
10.13699/j.cnki.1001-6821.2017.16.006
- VernacularTitle:溴吡斯的明片联合甲磺酸多沙唑嗪片治疗老年女性宫颈癌术后尿潴留的临床研究
- Author:
Kun-Hua SU
1
;
You-Bin HU
;
Jing-Ming MA
;
Li KOU
Author Information
1. 三峡大学第一临床医学院、宜昌市中心人民医院药剂科
- Keywords:
pyridostigmine bromide;
doxazosin mesylate;
cervical carcinoma in elderly women;
urinary retention
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(16):1537-1539
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of pyridostigmine combined with doxazosin mesylate in the treatment of elderly women with urinary retention after cervical cancer surgery.Methods A total of 52 cases of elderly women with urinary retention after cervical cancer surgery were randomly divided into control group (n =26) and treatment group (n =26).Patients in two groups were given routine physical stimulation.Control group was given doxazosin mesylate 4 mg qd.Treatment group was given pyridostigmine bromide tablets 60 mg tid,on the basis of control group.All patients were treated for 7 d.The clini cal efficacy,urodynamics and adverse drug reactions were observed intwo groups.Results After treatment,the total effective rates in treatment group and control group were 92.31％ (24/26 cases),65.38％ (17/26 cases),with significant difference(P ＜0.05).After treatment,the residual urine volume,maximum bladder capacity,bladder compliance,maximum urine flow rate,detrusor pressure at maximum urinary flow rate in treatment group were (40.14 ± 5.57)mL,(300.19 ±31.89)mL,(32.00 ±4.18)mL · cm H2O-1,(10.02 ± 1.43)mL · s-1,(25.71 ±3.14) cm H2O,had significant difference with those in control group,which were (69.88 ± 8.37)mL,(5.02 ± 0.53)mL,(56.39±6.19)cmH2O-1,(17.89 ±2.34)mL· s-1,(33.41 ±4.02)cm H2O(P＜0.05).The adverse drug reactions in treatment group were nausea and vomiting,diarrhea,total incidence of adverse drug reactions was 15.38％ (4/26 cases).The adverse drug reactions in control group were nausea and vomiting,diarrhea,the total incidence rate of adverse reaction was 11.54％ (3/26 cases,P ＞ 0.05).Conclusion Pyridostigmine combined with doxazosin mesylate have significant effect in the treatment of urinary retention after cervical cancer surgery in elderly women,and safety.
