Expressions of fragile histidine triad protein and B cell lymphoma-2 in gastric carcinoma and their correlation with Helicobacter pylori infection
10.13699/j.cnki.1001-6821.2017.15.015
- VernacularTitle:脆性三联组氨酸蛋白和B细胞淋巴瘤-2蛋白在胃癌组织中的表达及其与幽门螺旋杆菌感染的相关性研究
- Author:
Qing WANG
1
;
Hong-Wei XU
;
Yue-Qin QIAO
;
Han YU
Author Information
1. 青岛市第九人民医院消化内科
- Keywords:
gastric cancer tissue;
fragile histidine triad protein;
B cell lymphoma-2 protein;
Helicobacter pylori
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(15):1431-1433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of fragile histidine triad protein (FHIT) protein and B cell lymphoma-2 (Bcl-2) protein,and the clinical relationships between their expression and Helicobacter pylori infection in gastric carcinoma Methods A total of 36 cases of gastric cancer tissues,17 cases of adjacent tissues and gastritis tissues were selected.The expressions of FHIT protein and Bcl-2 protein were detected by immunohistochemistry SP method,and the Helicobacter pylori infection was detected by the toluidine blue method and 14C breath test.Results The positive-expression rates of FHIT protein in gastric cancer,adjacent non-cancerous tissues and gastritis tissues were 44.44％,76.47％,70.59％.The positive-expression rates of Bcl-2 protein in gastric cancer,adjacent non-cancerous tissues and gastritis tissues were 63.89％,29.41％,35.29％.There were significant differences between the cancer tissues and adjacent non-cancerous tissues and gastritis tissues (all P ＜ 0.05).The expressions of FHIT protein and Bcl-2 protein in gastric carcinoma were negatively correlated (P ＜ 0.001).The positive-expression rates of FHIT protein in Helicobacterpylori positive and negative tissues were 57.69％ and 10.00％ respectively,and Bcl-2 protein were 42.31％ and 80.00％ respectively,and the differences were statistically significant (all P ＜ 0.05).Conclusion Expressions of FHIT protein and Bcl-2 protein are negatively related in gastric carcinoma,and Helicobacter pylori infection may influence the expressions of FHIT protein and Bcl-2 protein in gastric carcinoma,and they play an important role in the occurrence and development of gastric cancer.
