Clinical trial of sitagliptin tablets combined with insulin detemir injection in the treatment of senile type 2 diabetes mellitus
10.13699/j.cnki.1001-6821.2017.15.010
- VernacularTitle:西格列汀片联合地特胰岛素注射液治疗老年2型糖尿病的临床研究
- Author:
Yu-Pu LIU
1
;
Fang-Xin ZENG
;
Zu-Jiang PENG
;
Yuan TIAN
;
Lin QIU
Author Information
1. 达州市中西医结合医院内分泌科
- Keywords:
sitagliptin tablet;
insulin detemir injection;
type 2 diabetes mellitus;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(15):1415-1417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of sitagliptin tablets combined with insulin detemir injection in the treatment of senile type 2 diabetes mellitus (T2DM).Methods A total of 120 elderly patients with T2DM were randomly divided into control group and treatment group with 60 cases per group.Two groups received subcutaneous injection of insulin detemir once a night with initial dose of 0.2 U · kg-1.Control group received oral repaglinide 0.5-2.0 mg tid.Treatment group was given oral sitagliptin 100 mg qd.Two groups were treated for 12 weeks.The clinical efficacy,levels of blood glucose and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates of treatment and control groups were 95.00％ (57/60 cases) and 76.67％ (46/60 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:the 2-hour postprandial blood glucose (2hPG) were (8.20±1.14),(9.87 ±1.64)mmol · L-1;the insulin dosages were (20.81 ±6.32),(39.86 ±5.40) U · d-1;hyperglycemia time ratios were (2.26 ± 1.85)％ and (15.93 ± 10.76)％ for 2 h PG ＞ 11.1 mmol · L-1;hypoglycemia time ratios were (2.64 ± 1.99)％,(3.60 ±2.84)％;blood glucose fluctuation coefficients were 1.50 ± 0.26 and 2.47 ± 0.39,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions were based on hypoglycemia in two groups.The incidence rates of hypoglycemia were 1.67％ and 10.00％ in treatment and control groups with significant difference (P ＜ 0.05).Conclusion Sitagliptin tablets combined with insulin detemir injection can effectively control the blood glucose on the elderly patients with T2DM,decrease the fluctuation of blood glucose,and reduce the incidence of hypoglycemia.
